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KMID : 0191120100250101487
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Journal of Korean Medical Science
2010 Volume.25 No. 10 p.1487 ~ p.1491
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Plasma C-Reactive Protein and Endothelin-1 Level in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension
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Kwon Yong-Soo
Chi Su-Young
Shin Hong-Joon
Kim Eun-Young
Yoon Byeong-Kab
Ban Hee-Jung
Oh In-Jae
Kim Kyu-Sik
Kim Young-Chul
Lim Sung-Chul
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Abstract
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Pulmonary hypertension is a frequent complication of chronic obstructive pulmonary disease (COPD) and associated with a worse survival and increased risk of hospitalization for exacerbation of COPD. However, little information exists regarding the potential role of systemic inflammation in pulmonary hypertension of COPD. The purpose of the present study was to investigate the degree of C-reactive protein (CRP) and endothelin-1 (ET-1) levels in COPD patient with and without pulmonary hypertension. The levels of CRP and ET-1 were investigated in 58 COPD patient with pulmonary hypertension and 50 patients without pulmonary hypertension. Pulmonary hypertension was defined as a systolic pulmonary artery pressure (Ppa) ≥35 mmHg assessed by Doppler echocardiography. Plasma CRP and ET-1 levels were significantly higher in patients with pulmonary hypertension than in patients without hypertension. There were significant positive correlations between the plasma ET-1 level and CRP level in the whole study groups. For COPD patients, systolic Ppa correlated significantly with plasma CRP levels and plasma ET-1 levels. These findings support a possibility that CRP and ET-1 correlate to pulmonary hypertension in COPD patients.
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KEYWORD
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Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, C-Reactive Protein, Endothelin-1
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